Department of Obstetrics, Gynecology and Reproductive Biology
Michigan State University College of Human Medicine
In non-pregnant female mammals of reproductive age, ovulation (the releasing of eggs from the ovaries) and menstruation (the shedding of the uterine lining) occurs each month. This repeated cellular turnover causes stress and inflammation, which puts females at risk for developing certain reproductive-tract cancers.
The goal of our research is to discover which genes and signaling pathways play a critical role in determining cellular homeostasis in the female reproductive system (particularly in ovarian cancer and associated benign disease) and how cells within the female reproductive tract cope with the iterative tissue repair processes and inflammation necessary for maintaining reproductive competence. We aim to provide a mechanistic understanding of how epigenetic or chromatin-regulated processes maintain cellular homeostasis and prevent tumorigenesis in the female reproductive tract in response to environmental or intracellular stress and the ensuing activation of cellular signaling.
Dr. Chandler received his B.S. in Biology at Tennessee Technological University, and his Ph.D. in Molecular Physiology and Biophysics from Vanderbilt University. He was awarded a prestigious postdoctoral fellowship from the American Cancer Society to pursue postdoctoral research in the Laboratory of Dr. Terry Magnuson and Department of Genetics at the University of North Carolina at Chapel Hill. He was also awarded an Ann Schreiber Mentored Investigator Award from the Ovarian Cancer Research Fund to support his new research endeavors in the area of chromatin structure, epigenetics and gynecologic cancer. Dr. Chandler is an Assistant Professor in Department of Obstetrics, Gynecology and Reproductive Biology at Michigan State University. His lab is currently located in Van Andel Institute.